Mitochondrial-Encoded Peptide MOTS-c Prevents Pancreatic Islet Cell Senescence to Delay Diabetes

Plain-language summary

This study examined how MOTS-c affects pancreatic islet aging using aged mouse models and nonobese diabetic mice. Treatment with MOTS-c reduced islet cell senescence by modulating nuclear gene expression and key metabolites involved in beta-cell aging, and improved glucose intolerance in treated animals. The researchers also observed that circulating MOTS-c levels are lower in human type 2 diabetes patients compared to healthy controls, supporting its relevance to metabolic disease research.