Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

Plain-language summary

This systematic review analyzed 36 studies (35 preclinical, 1 clinical) published between 1993 and 2024, finding that BPC-157 enhances growth hormone receptor expression, promotes angiogenesis, and reduces inflammatory cytokines. In preclinical models, the peptide improved functional, structural, and biomechanical outcomes across muscle, tendon, ligament, and bone injury models. A single human pilot study reported that 7 of 12 patients with chronic knee pain experienced relief lasting over six months following a single intra-articular injection.