The Stable Gastric Pentadecapeptide BPC 157: Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity

Plain-language summary

This 2024 review highlights BPC-157's broad cytoprotective and pleiotropic properties, noting its stability in human gastric juice and its capacity to counteract disturbances across multiple neurotransmitter systems including dopamine, serotonin, glutamate, GABA, and the NO system. The authors present a network of evidence suggesting BPC-157 modulates relevant receptors—including VEGF and growth hormone receptors—and may act as a mediator of cytoprotection across organ systems. The study underscores BPC-157's potential relevance to both gastrointestinal and neurological research models.